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Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

2014; National Academy of Sciences; Volume: 111; Issue: 42 Linguagem: Inglês

10.1073/pnas.1416714111

1091-6490

Yuchun Luo, Xiangna Cai, Sucai Liu, Sen Wang, Claudia A. Nold‐Petry, Marcel F. Nold, Philip Bufler, David A. Norris, Charles A. Dinarello, Mayumi Fujita,

Dermatology and Skin Diseases

Significance The skin develops antigen-specific immune response, called “allergic contact dermatitis” in humans and “contact hypersensitivity” (CHS) in mice. IL-1 family member IL-37 expression in transgenic mice (IL-37tg) inhibits innate immune responses. In this study we show that DCs from IL-37tg mice exhibit diminished CHS response to an antigen-specific exposure. Although DCs from IL-37tg mice maintain migratory capacity to lymph nodes, they fail to activate T cells effectively; instead, they promote generation of T regulatory cells, a characteristic of semimature DCs that dampen adaptive immune response. Thus, IL-37 emerges as an inhibitor of adaptive immunity.