Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease
1996; Elsevier BV; Volume: 2; Issue: 5 Linguagem: Inglês
10.1016/1357-4310(96)88772-7
ISSN1878-4178
Autores Tópico(s)Immune cells in cancer
ResumoThe appearance of specific types of leukocytes in inflammatory infiltrates may be governed by cell-specific chemoaatractants called chemokines. In particular, monocyte chemoattractant protein 1 (MCP-1) has been implicated in diseases characterized by monocyte-rich infiltrates, including atherosclerosis, rheumatoid arthritis and multiple sclerosis. While we are beginning to understand the structural determinants that govern the activities of MCP-1 in vitro, we know much less about its physiological functions in vivo and its pathogenetic role in disease. However, recent data from genetically modified mice have begun to place MCP-1 in a central position in monocyte trafficking and activation.
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