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Chromosomal Abnormalities in Cancer

2008; Massachusetts Medical Society; Volume: 359; Issue: 7 Linguagem: Inglês

10.1056/nejmra0803109

1533-4406

Stefan Fröhling, Hartmut Döhner,

Genomic variations and chromosomal abnormalities

This review gives an account of chromosomal aberrations in cancer cells. Such abnormalities have typically been associated with hematologic cancers, but recent work has shown a variety of chromosomal changes in solid tumors, including prostate cancer and non–small-cell lung cancer. The authors point out that some of the chromosomal abnormalities have revealed targets for cancer treatment, and others have clinical application in the diagnosis of certain types of neoplasms and in the formulation of a prognosis.