Produção Nacional
Revisado por pares
Bisabolanes from the Red Alga Laurencia s coparia
2006; American Chemical Society; Volume: 69; Issue: 7 Linguagem: Inglês
10.1021/np060235+
ISSN1520-6025
AutoresDanilo Davyt, Rafael Fernández, Leopoldo Suescun, Álvaro W. Mombrú, Jenny Saldaña, Laura Domínguez, Mutuê T. Fujii, Eduardo Manta,
Tópico(s)Marine and coastal plant biology
ResumoThree novel halogenated beta-bisabolene sesquiterpenoids (1-3), together with two know triquinane alcohol sesquiterpenes (6 and 7), were isolated from the red alga Laurencia scoparia and their structures elucidated by spectroscopic methods. Single-crystal X-ray crystallography allowed us to confirm the structure of 1 as well as to determine the absolute configuration of all stereocenters. To the best of our knowledge, the isolation of beta-bisabolenes from the genus Laurencia has no precedent in the literature. Compound 1 showed weak in vitro anthelmintic activity against parasitant stage (L4) Nippostrongilus brasiliensis.
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