Portal de Periódicos da CAPES

Habituation of blink reflexes in Parkinsonian patients under levodopa and amantadine treatment

1972; Elsevier BV; Volume: 17; Issue: 2 Linguagem: Inglês

10.1016/0022-510x(72)90136-0

1878-5883

C Messina, A. E. Di Rosa, Francesco Tomasello,

Ophthalmology and Eye Disorders

The habituation of the polysynaptic component of the blink reflexes has been studied in 10 Parkinsonian patients treated with levodopa and in 9 others who received intravenous amantadine. Under pre-treatment conditions all subjects showed a clear-cut defect of habituation of this reflex. Both levodopa and amantadine produced some recovery of habituation, levodopa being more effective than amantadine. Electrophysiological recordings have been compared to clinical phenomena recorded in the same patients under pre-treatment conditions and after both drugs were administered.