The Influence of Some Vitamin Deficient Diets on a Substance Characteristic of the Epidermis of the Mouse, Rat and Man****From the Wernse Laboratory for Cancer Research, Washington University Medical School, St. Louis, Mo.**Supported by a grant from the Charles F. Kettering Foundation and by a grant-in-aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council.
1954; Elsevier BV; Volume: 23; Issue: 2 Linguagem: Inglês
10.1038/jid.1954.87
ISSN1523-1747
Autores Tópico(s)Effects and risks of endocrine disrupting chemicals
ResumoRecent investigations have demonstrated that the epidermis of the mouse, rat and man contains a polarographically reducible substance not present in other tissues (mouse brain, liver, kidney, lung, heart, lymph nodes, skeletal muscle, spleen, pancreas and blood) (1, 2). This characteristic substance of epidermis also absorbs specifically in the ultraviolet and its absorption maximum is pH dependent (3). Since the reducible substance in the epidermis of the mouse, rat and man disappears when this tissue becomes carcinomatous, (3, 4) experiments were undertaken to ascertain whether other conditions such as various vitamin deficiencies, some of which affect the epidermis, would have any influence upon the properties of the epidermal substance.
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