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Solid-phase synthesis of 1-substituted 4,5-dihydro-1,2,4-triazin-6-ones

2001; Elsevier BV; Volume: 42; Issue: 37 Linguagem: Inglês

10.1016/s0040-4039(01)01095-4

1873-3581

Blanca Martı́nez-Teipel, Enrique L. Michelotti, Martha J. Kelly, Damian G. Weaver, Francis V. Acholla, Kebede Beshah, Jordi Teixidó,

Click Chemistry and Applications

The solid-phase synthesis of 1-substituted 4,5-dihydro-1,2,4-triazin-6-ones from imidate esters and substituted hydrazines is reported. The synthesis starts with the reaction of imidic esters with polymer-bound glycine to form the imidate esters. A rehearsal library of 59 compounds was synthesized.