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Pathological aspects of lipid peroxidation

2010; Taylor & Francis; Volume: 44; Issue: 10 Linguagem: Inglês

10.3109/10715762.2010.498478

1071-5762

Anne Nègre‐Salvayre, Nathalie Augè, Victòria Ayala, Hüveyda Başağa, Jordi Boada, Rainer Brenke, Sarah J. Chapple, Guy Cohen, János Fehér, Tilman Grune, Gabriella Lengyel, Giovanni E. Mann, Reinald Pamplona, Giuseppe Poli, Manuel Portero‐Otín, Yael Riahi, Robert Salvayre, Shlomo Sasson, José C. E. Serrano, Ofer Shamni, Werner Siems, Richard Siow, Ingrid Wiswedel, Kamelija Žarković, Neven Žarković,

Antioxidant Activity and Oxidative Stress

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.