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Schistosoma mansoni: Role in vivo of complement in primary infection of mice

1982; Elsevier BV; Volume: 54; Issue: 1 Linguagem: Inglês

10.1016/0014-4894(82)90108-4

1090-2449

F Santoro, B. Vandemeulebroucke, M.C. Liebart, A Capron,

Trace Elements in Health

Abstract The role of complement in the control of the primary Schistosoma mansoni infection in mice was investigated in vivo . The number of recovered adult schistosomes 6–7 weeks postinfection was used as a parasitological criterion of immunity. No significant difference in the worm burden was observed between C5-sufficient and C5-deficient mice. In contrast, when cobra venom factor (CVF) was injected into normal or C5-deficient mice 24 hr before challenge, a significant increase of the worm burden was noticed in comparison to the untreated mice. These results indicated that, although C5 and probably the late complement components are not essential for the control of the primary infection, the alternative pathway and some of its components are involved. In fact, the injection of C3 2 hr before infection of CVF-treated mice completely restored the immunity. A role for C3, in association with effector cells, in the nonspecific immunity occurring in the first hours after a primary S. mansoni infection is suggested.