Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(ii) complex
2011; Royal Society of Chemistry; Volume: 40; Issue: 38 Linguagem: Inglês
10.1039/c1dt10219b
ISSN1477-9234
AutoresDenis S. Salnikov, Radu Silaghi‐Dumitrescu, Sergei V. Makarov, Rudi van Eldik, Gerry R. Boss,
Tópico(s)Metal-Catalyzed Oxygenation Mechanisms
ResumoEvidence for the formation of a unique, six-coordinate cobalamin(II) complex with the anion-radical SO2− during the reduction of aquacobalamin(III) by sodium dithionite, was obtained from spectrophotometric and EPR measurements. The pKa value of the weakly coordinated dimethylbenzimidazole group was found to be 4.8 ± 0.1 at 25 °C.
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