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Impaired clearance of escherichia coli bacteremia in early biliary obstruction

1989; Elsevier BV; Volume: 157; Issue: 2 Linguagem: Inglês

10.1016/0002-9610(89)90530-8

1879-1883

Carol E. H. Scott‐Conner, James B. Grogan, Kenneth S. Scher, Jack Bernstein,

Drug Transport and Resistance Mechanisms

Adult male rats underwent common bile duct ligation or sham celiotomy. At intervals of 7 and 14 days postoperatively, bacteremia was induced by intravenous injection of 109 Escherichia coli or intraperitoneal injection of 106 E. coli. Serial quantitative blood cultures and quantitative whole organ cultures were obtained. One week after surgery, clearance of bacteremia was impaired in all of the animals. Clearance of intraperitoneally injected E. coli was less efficient in the duct ligation rats. Fourteen days postoperatively, clearance of bacteremia induced by intravenous or intraperitoneal injection had improved in the sham celiotomy rats but was still significantly impaired in the duct ligation rats. An increased number of viable E. coli were recovered from the lungs of duct ligation rats after intravenous administration. We found that rats with obstructive jaundice do not respond normally to a bacteremic challenge. This impairment in reticuloendothelial function can be noted as early as 1 week after common duct ligation.