Portal de Periódicos da CAPES

PREPARATION OF THE HONEYCOMB PATTERNED POROUS FILM OF BIODEGRADABLE POLYMER FOR TISSUE ENGINEERING SCAFFOLDS

2002; World Scientific; Volume: 01; Issue: 05n06 Linguagem: Inglês

10.1142/s0219581x02000905

0219-581X

Katsuhisa Sato, Kiyoshi Hasebe, Masaru Tanaka, Masafumi Takebayashi, Kazutaka Nishikawa, Masatsugu Shimomura, Tomoaki Kawai, Michiaki Matsushita, Satoru Todo,

3D Printing in Biomedical Research

Fabrication and surface modification of a cell scaffold are very important in tissue engineering. In this study, the effects of pore size and surface wettability on hepatocyte adhesion and morphology was studied, using the porous poly-ε-caprolactone (PCL) film prepared by a simple casting technique. The degree of spreading of hepatocyte was enhanced with the decrease of the pore size (~10 μm). Hepatocyte motility and spreading were restricted on the patterned film having cellular-sized pores (ca. 20 μm). Partial hydrolysis of the film surface enhanced the migration and spheroid formation of the cultured hepatocyte.