Incidence of iris melanoma in western Norway
2007; Wiley; Volume: 86; Issue: 1 Linguagem: Inglês
10.1111/j.1600-0420.2007.01011.x
ISSN1755-3768
Autores Tópico(s)Ocular Infections and Treatments
ResumoActa OphthalmologicaVolume 86, Issue 1 p. 116-117 Free Access Incidence of iris melanoma in western Norway Jørgen Krohn, Jørgen Krohn Department of Clinical Medicine, Section of Ophthalmology, University of Bergen, Bergen, Norway Department of Ophthalmology, Haukeland University Hospital, Bergen, NorwaySearch for more papers by this authorOlav Dahl, Olav Dahl Institute of Medicine, Section for Oncology, University of Bergen, Bergen, Norway Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, NorwaySearch for more papers by this author Jørgen Krohn, Jørgen Krohn Department of Clinical Medicine, Section of Ophthalmology, University of Bergen, Bergen, Norway Department of Ophthalmology, Haukeland University Hospital, Bergen, NorwaySearch for more papers by this authorOlav Dahl, Olav Dahl Institute of Medicine, Section for Oncology, University of Bergen, Bergen, Norway Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, NorwaySearch for more papers by this author First published: 28 June 2008 https://doi.org/10.1111/j.1600-0420.2007.01011.xCitations: 6 Jørgen KrohnDepartment of OphthalmologyHaukeland University HospitalN-5021 BergenNorwayTel: + 47 55 97 41 00Fax: + 47 55 97 41 43Email: jorgen.krohn@helse-bergen.no AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Editor, Malignant melanoma may arise in any part of the uveal tract, with increasing frequency from the iris to the ciliary body and choroid. The posterior segment of the eye (choroid and ciliary body) is the most common site for uveal melanomas and accounts for 95–98% of cases, whereas only 2–5% are located on the iris (Jensen 1970; Raivio 1977; Shields et al. 2001). As epidemiological data on iris melanoma in Norway are scarce, we analysed the incidence of this disease in our region. The clinical records of all patients with primary iris melanoma referred to Haukeland University Hospital between January 1st, 1993 and December 31st, 2005 were reviewed. Haukeland University Hospital is the regional hospital for the three western counties of Norway: Rogaland, Hordaland and Sogn og Fjordane. In order to establish the incidence of iris melanoma in western Norway, the number of residents treated elsewhere was collected from the Cancer Registry of Norway and by reviewing the medical records at other hospitals in the region. Population figures by gender, age, county and calendar period were obtained from Statistics Norway (Statistisk Sentralbyrå, Oslo, Norway). The difference in the incidence of iris melanoma between women and men was analysed by chi-square test, and p-values < 0.05 were considered statistically significant. Age-adjusted incidence rates were calculated by a direct method using weights according to the European Standard Population. The study was registered and approved by the Norwegian Social Science Data Services, and followed the official ethical regulations for clinical research. During the period from 1993 to 2005, a total of 13 patients (six women and seven men) received a histologically verified diagnosis of primary iris melanoma, accounting for 10% of all uveal melanomas over the 13-year period. The median age at the time of diagnosis was 45 years (mean 51 years, range 25–81 years). The right eye was involved in seven and the left eye in six patients. Eleven patients were treated at Haukeland University Hospital and two were treated at other hospitals in Norway. During the study period, the average population in the region was 908 924. Each gender was analysed separately and the patients were divided into different age groups. The crude incidence of primary iris melanoma was 0.12 for women and 0.10 for men per 100 000 person-years; the corresponding age-adjusted incidence rates were 0.10 and 0.09, respectively. The age-specific incidence was higher in men (0.41) than in women (0.28) at 70–89 years of age. However, there was no statistically significant difference in incidence between the genders in any age group. In the present study, we estimated the incidence of primary iris melanoma in a well defined and homogenous population, and made efforts to include all affected patients living in the three counties of western Norway. The incidence of iris melanoma was relatively high compared with those in many other studies, where incidence rates have varied between 0.04 and 0.06 (McGalliard & Johnston 1989; Jensen 1993; Isager et al. 2005). However, an incidence rate of 0.09 was recently reported from New Zealand (Michalova et al. 2001) and, according to Isager et al. (2005), the incidence of iris melanoma in Denmark increased significantly during the period from 1943 to 1997. By contrast with posterior uveal melanoma, iris melanoma may therefore follow the time trend of cutaneous melanoma, which has shown a considerable increase in incidence during the last several decades. 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