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Copper(II)-Catalyzed Exo and Enantioselective Cycloadditions of Azomethine Imines

2008; American Chemical Society; Volume: 10; Issue: 14 Linguagem: Inglês

10.1021/ol800904t

1523-7060

Mukund P. Sibi, Digamber Rane, Levi M. Stanley, Takahiro Soeta,

Chemical Synthesis and Analysis

A strategy for exo and enantioselective 1,3-dipolar cycloaddition of azomethine imines to 2-acryloyl-3-pyrazolidinone is described. The corresponding cycloadducts are isolated with high diastereoselectivities (up to >96:4 exo/endo) and enantioselectivities (up to 98% ee).