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Cytokines and the inception of CD8 T cell responses

2011; Elsevier BV; Volume: 32; Issue: 4 Linguagem: Inglês

10.1016/j.it.2011.01.004

1471-4981

Maureen A. Cox, Laurie E. Harrington, Allan Zajac,

Immunotherapy and Immune Responses

The activation and differentiation of CD8 T cells is a necessary first step that endows these cells with the phenotypic and functional properties required for the control of intracellular pathogens.The induction of the CD8 T cell responses typically results in the development of a massive overall population of effector cells, comprised of both highly functional but short-lived terminally differentiated cells, as well as a smaller subset of precursors that are predisposed to survive and transition into the memory T cell pool.In this article we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation and also highlight the potential counterbalancing role of IL-21.