The hexosemonophosphate shunt and glutathione reduction in guinea pig brain tissue: Changes caused by chlorpromazine, amytal, and malonate
1968; Elsevier BV; Volume: 123; Issue: 1 Linguagem: Inglês
10.1016/0003-9861(68)90108-2
ISSN1096-0384
Autores Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThe effects of chlorpromazine, amytal, and malonate on the oxidation of specifically 14C-labelled glucoses and the reduction of oxidized glutathione by guinea pig brain preparations have been investigated. All three compounds inhibited the oxidation of glucose by the tricarboxylic acid cycle. Changes in the reduction of glutathione caused by the compounds were accompanied by parallel changes in the activity of the hexosemonophosphate shunt pathway for glucose metabolism. Chlorpromazine increased, while amytal and malonate decreased, both activities. The results appear to indicate that the hexosemonophosphate shunt may serve a major role in brain for the maintenance of glutathione in the reduced state.
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