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A Neurohormone Regulating both Methyl Farnesoate Synthesis and Glucose Metabolism in a Crustacean

1997; Elsevier BV; Volume: 237; Issue: 3 Linguagem: Inglês

10.1006/bbrc.1997.6977

1090-2104

Lei Liu, Hans Laufer, Yajun Wang, Timothy K. Hayes,

Crustacean biology and ecology

Methyl farnesoate (MF) has been identified as a juvenile hormone-like compound in crustacea which has central roles in the regulation of development and reproduction. To study the regulation of MF synthesis, we isolated a neuropeptide which inhibits MF synthesis from the neurohemal organ--sinus gland X-organ complex of the spider crabLibinia emarginata.The primary structure of this neuropeptide has been determined. It has 72 amino acid residues (deduced molecular mass 8490.5 Da) with pyroglutamic acid at the N-terminus and NH2at the C-terminus. It shares a high percentage of sequence identity with other sinus gland neuropeptids which form the unique family of CHH neuropeptides of crustacea. Activity studies showed that this neurohormone has dual effects: it inhibited MF synthesisin vitroand had hyperglycemic activity when injected into crabs.