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In vitro cytotoxic, antileishmanial and antifungal activities of ethnopharmacologically selected Gabonese plants

2005; Elsevier BV; Volume: 102; Issue: 2 Linguagem: Inglês

10.1016/j.jep.2005.06.011

1872-7573

Marow Lamidi, Caroline DiGiorgio, F. Delmas, Anne Favel, C. Eyele Mve-Mba, M.L. Rondi, Évelyne Ollivier, L. Nze-Ekekang, G. Balansard,

Insect Pest Control Strategies

Seventy-seven crude extracts from leaves and stem barks of 15 Gabonese plants used in traditional medicine were evaluated for their cytotoxic, antileishmanial and antifungal activities. Most of the extracts exhibited cytotoxic activities toward human monocytes, and most particularly the hydromethanolic 50% (v/v) fraction of Ganophyllum giganteum leaves (IC(50)=1.3 microg/ml) as well as the methanolic extracts of Polyalthia suaveolens, Dioscorea preussii, Augouardia letestui leaves and Cola lizae stem barks (IC(50)<5 microg/ml). The methanolic extract of Polyalthia suaveolens displayed a strong antiproliferative activity against the promastigote form of Leishmania infantum parasites and presented a good antifungal activity on all the tested strains (IC(50) 100 microg/ml) and displayed interesting antileishmanial activity against the intracellular amastigote form of the parasite (IC(50)=5.6 and 12.4 microg/ml), respectively. However, the antifungal activity observed for the crude extract could not be recovered in the corresponding fractions.