Role of Advanced 2 And 3-dimensional Ultrasound For Detecting Prostate Cancer
2002; Lippincott Williams & Wilkins; Volume: 168; Issue: 6 Linguagem: Inglês
10.1016/s0022-5347(05)64159-6
ISSN1527-3792
AutoresK.C. Balaji, William R. Fair, Ernest J. Feleppa, Christopher R. Porter, Harold Tsai, Tian Liu, Andrew Kalisz, Š. Urban, John H. Gillespie,
Tópico(s)AI in cancer detection
ResumoNo AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Dec 2002Role of Advanced 2 And 3-dimensional Ultrasound For Detecting Prostate Cancer K.C. BALAJI, WILLIAM R. FAIR, ERNEST J. FELEPPA, CHRISTOPHER R. PORTER, HAROLD TSAI, TIAN LIU, ANDREW KALISZ, STELLA URBAN, and JOHN GILLESPIE K.C. BALAJIK.C. BALAJI More articles by this author , WILLIAM R. FAIRWILLIAM R. FAIR More articles by this author , ERNEST J. FELEPPAERNEST J. FELEPPA More articles by this author , CHRISTOPHER R. PORTERCHRISTOPHER R. PORTER More articles by this author , HAROLD TSAIHAROLD TSAI More articles by this author , TIAN LIUTIAN LIU More articles by this author , ANDREW KALISZANDREW KALISZ More articles by this author , STELLA URBANSTELLA URBAN More articles by this author , and JOHN GILLESPIEJOHN GILLESPIE More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64159-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We explored the clinical usefulness of spectrum analysis and neural networks for classifying prostate tissue and identifying prostate cancer in patients undergoing transrectal ultrasound for diagnostic or therapeutic reasons. Materials and Methods: Data on a cohort of 215 patients who underwent transrectal ultrasound guided prostate biopsies at Memorial-Sloan Kettering Cancer Center, New York, New York were included in this study. Radio frequency data necessary for 2 and 3-dimensional (D) computer reconstruction of the prostate were digitally recorded at transrectal ultrasound and prostate biopsy. The data were spectrally processed and 2-D tissue typing images were generated based on a pre-trained neural network classification. We used manually masked 2-D tissue images as building blocks for generating 3-D tissue images and the images were tissue type color coded using custom software. Radio frequency data on the study cohort were analyzed for cancer probability using the data set pre-trained by neural network methods and compared with conventional B-mode imaging. ROC curves were generated for the 2 methods using biopsy results as the gold standard. Results: The mean area under the ROC curve plus or minus SEM for detecting prostate cancer for the conventional B-mode and neural network methods was 0.66 ± 0.03 and 0.80 ± 0.05, respectively. Sensitivity and specificity for detecting prostate cancer by the neural network method were significantly increased compared with conventional B-mode imaging. In addition, the 2 and 3-D prostate images provided excellent visual identification of areas with a higher likelihood of cancer. Conclusions: Spectrum analysis could significantly improve the detection and evaluation of prostate cancer. Routine real-time application of spectrum analysis may significantly decrease the number of false-negative biopsies and improve the detection of prostate cancer at transrectal ultrasound guided prostate biopsy. It may also provide improved identification of prostate cancer foci during therapeutic intervention, such as brachytherapy, external beam radiotherapy or cryotherapy. In addition, 2 and 3-D images with prostate cancer foci specifically identified can help surgical planning and may in the distant future be an additional reliable noninvasive method of selecting patients for prostate biopsy. 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Google Scholar From the University of Nebraska Medical Center, Omaha, Nebraska, Haelth, Riverside Research Institute and New York Presbyterian Medical Center, New York and State University of New York Medical Center, Stony Brook, New York, New York, Kaiser-Permanente, Los Angeles, California, and National Cancer Institute, Bethesda, Maryland© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 168Issue 6December 2002Page: 2422-2425 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsspectrum analysisultrasonographyimaging, three-dimensionalprostatic neoplasmsprostateMetricsAuthor Information K.C. BALAJI More articles by this author WILLIAM R. FAIR More articles by this author ERNEST J. FELEPPA More articles by this author CHRISTOPHER R. PORTER More articles by this author HAROLD TSAI More articles by this author TIAN LIU More articles by this author ANDREW KALISZ More articles by this author STELLA URBAN More articles by this author JOHN GILLESPIE More articles by this author Expand All Advertisement PDF downloadLoading ...
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