Increased paracetamol-induced hepatotoxicity after chronic alcohol consumption
1979; Elsevier BV; Volume: 91; Issue: 1 Linguagem: Inglês
10.1016/0006-291x(79)90628-4
ISSN1090-2104
AutoresRolf Teschke, Gerd Stutz, G Strohmeyer,
Tópico(s)Alcohol Consumption and Health Effects
ResumoFemale rats were pair-fed nutritionally adequate liquid diets containing either ethanol (36 % of total cal.) or isocaloric carbohydrates (controls) for 4 weeks. Compared to controls, chronic alcohol consumption led to slightly increased activities of various hepatic enzymes in the serum. Paracetamol administered 18 hours after ethanol withdrawal resulted within 18 hours in a significant increase of serum GOT and GPT activities, which was much more pronounced in rats fed ethanol chronically than in their pair-fed controls. Thus, chronic alcohol consumption predisposes to increased hepatotoxicity due to paracetamol.
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