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Topical flurbiprofen treatment of periodontitis in beagles

1988; Wiley; Volume: 23; Issue: 3 Linguagem: Inglês

10.1111/j.1600-0765.1988.tb01352.x

1600-0765

Ray Williams, Marjorie K. Jeffcoat, T. Howard Howell, M. Sai Bhargava Reddy, Herbert G. Johnson, C. M. Hall, P. Goldhaber,

Proteoglycans and glycosaminoglycans research

The effect of the non‐steroidal anti‐inflammatory drug flurbiprofen, topically applied, on the progression of periodontal disease was studied in 12 beagle dogs over a 13‐month period. Standardized radiographs were used to measure the rate of bone loss. Following a 6‐month pretreatment baseline period, 6 dogs were treated daily with 0.3 mg flurbiprofen gently applied to the gingival margin in 1 ml of gel vehicle. Six untreated dogs served as controls. In the untreated control dogs the rate of bone loss in the treatment period did not change significantly from baseline, although the rate was elevated by 38%. In contrast, the rate of bone loss significantly decreased by 71% from baseline in the flurbiprofen‐treated dogs. The untreated control dogs lost 10 teeth during the treatment period whereas the topical flurbiprofen‐treated dogs lost only 1 tooth. The data indicate that topical application of flurbiprofen in a gel vehicle significantly inhibits alveolar bone loss in beagles over a 7‐month treatment period. The data also indicate that topical flurbiprofen is associated with the loss of considerably less teeth than in untreated control dogs over the 7‐month treatment period.