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Ultraviolet-Induced Corneal Tumors in Different Species and Strains of Animals**From the Departments of Dermatology and Pathology, Baylor University College of Medicine, Houston, Texas.

1964; Elsevier BV; Volume: 43; Issue: 5 Linguagem: Inglês

10.1038/jid.1964.177

1523-1747

Robert G. Freeman, John M. Knox,

Photodynamic Therapy Research Studies

Animals repeatedly subjected to ultraviolet irradiation develop many types of neoplasms, the type varying with the light source, dosage, species, strain and other factors (1, 2). Most such studies have been concerned with the production of skin tumors. However, the eyes of these animals also are subjected to irradiation, and carcinomas of the eyelids or neoplasms of ocular structures may result (3—6). After observing blindness due to corneal tumors in a group of pigmented rats irradiated with ultraviolet, we performed the following biologic and histopathologic experiments to evaluate the role of pigment and species difference in the formation of these tumors.