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Acute renal failure and myopathy after treatment with aminocaproic acid.

1980; BMJ; Volume: 281; Issue: 6233 Linguagem: Inglês

10.1136/bmj.281.6233.115-a

0959-8138

Chandrima Biswas, Douglas A. Milligan, Suhas D. Agte, D H Kenward, P J Tilley,

Pharmacological Effects and Toxicity Studies

Reversal of premature hair greying in adult coeliac diseaseThere is no known association between premature greying of the hair and the subsequent diagnosis of adult coeliac disease.I report two cases in which the hair colour turned completely during the third decade and remained unchanged until adult coeliac disease was diagnosed at least 20 years later.In both cases a reversal of the colour change began a few weeks after starting a gluten-free diet. Case reports(1) The patient, a man, had had dark brown hair until the age of 25.Discoloration progressed until at the age of 30 the scalp hair was snow white.Other body hair was unaffected and he remained in good health.At the age of 53 he was admitted to hospital after an accident and was found to be anaemic.The results of investigations, including jejunal biopsy, were consistent with adult coeliac disease.Institution of a gluten-free diet led to resolution of the anaemia.Within three months of starting the diet his hair was noticeably darker at the temples.Within five years his hair was quite Hai badin reate tocliicareapsofadutcelic isae Hair banding related to c'linical relapse of adult coehiac disease.dark but with streaks of grey, appropriate for his age of 58.Later his bowel action of two soft stools daily changed to one firm stool daily, but he could not remember if his bowel action had ever been different in his youth.A deliberate gluten meal caused diarrhoea, which settled over six weeks, and the freshly emerging hair became light grey once more, returning to the darker colour as the diarrhoea settled.A second gluten meal caused a repetition and obvious bands could be seen (figure).(2) The patient, a woman, had lost her dark brown hair colour during her late thirties alnd became completely white by the age of 43.She had recurrent iron-deficient anaemia which was attributed to menorrhagia until after the menopause,when she was investigated.The findings, including jejunal biopsy, suggested adult coeliac disease.Within a few weeks of starting a glutenfree diet at the age of 58 her hairdresser commented that her hair was growing out darker, and by the age of 63 its appearance strikingly resembled that of the first patient.The hair change was restricted to scalp hair and there was no alteration of bowel habit, but she felt much better. CommentThis report illustrates two grave consequences of treatment with aminocaproic acid, each of which is potentially lethal.The onset of acute massive myonecrosis six weeks after beginning treatment on 18 July