Portal de Periódicos da CAPES

Epidemiology of Escherichia coli , Klebsiella Species, and Proteus mirabilis Strains Producing Extended-Spectrum β-Lactamases From Clinical Samples in the Kinki Region of Japan

2012; Oxford University Press; Volume: 137; Issue: 4 Linguagem: Inglês

10.1309/ajcp48pdvkwqoxez

1943-7722

Tatsuya Nakamura, Masaru Komatsu, Katsutoshi Yamasaki, Saori Fukuda, Yugo Miyamoto, Takeshi Higuchi, Tamotsu Ono, Hisaaki Nishio, Noriyuki Sueyoshi, Kenji Kida, Kaori Satoh, Hirofumi Toda, Masahiro Toyokawa, Isao Nishi, Masako Sakamoto, Masahiro Akagi, Isako Nakai, Tomomi Kofuku, Tamaki Orita, Yasunao Wada, Takuya Zikimoto, Chihiro Koike, Shohiro Kinoshita, Itaru Hirai, Hakuo Takahashi, Nariaki Matsuura∥, Yoshimasa Yamamoto,

Pharmaceutical and Antibiotic Environmental Impacts

In the present study, nonduplicate, clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella spp, and Proteus mirabilis were collected during a 10-year period from 2000 to 2009 at several hospitals in the Kinki region, Japan. The detection rate of E coli markedly increased from 0.24% to 7.25%. The detection rate of Klebsiella pneumoniae increased from 0% to 2.44% and that of P mirabilis from 6.97% to 12.85%. The most frequently detected genotypes were the CTX-M9 group for E coli, the CTX-M2 group for K pneumoniae, and the CTX-M2 group for P mirabilis. E coli clone O25:H4-ST131 producing CTX-M-15, which is spreading worldwide, was first detected in 2007. The most common replicon type of E coli was the IncF type, particularly FIB, detected in 466 strains (69.7%). Of the K pneumoniae strains, 47 (55.3%) were of the IncN type; 77 P mirabilis strains (96.3%) were of the IncT type. In the future, the surveillance of various resistant bacteria, mainly ESBL-producing Enterobacteriaceae, should be expanded to prevent their spread.