Portal de Periódicos da CAPES

Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

1999; Elsevier BV; Volume: 11; Issue: 5 Linguagem: Inglês

10.1016/s0955-0674(99)00014-9

1879-0410

Kozo Kaibuchi, Shinya Kuroda, Masaki Fukata, Masato Nakagawa,

Hippo pathway signaling and YAP/TAZ

Reports in the past two years have shown that Cdc42, Rac1, and Rho — belonging to the Rho small GTPase family — participate in the regulation of cadherin-mediated cell–cell adhesion. IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and β-catenin and induces the dissociation of α-catenin from the cadherin–catenins complex leading to disruption of cell–cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell–cell adhesion acting through IQGAP1.