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Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast
2000; Wiley; Volume: 30; Issue: 1 Linguagem: Inglês
10.1002/1098-2264(2000)9999
ISSN1098-2264
AutoresElida P.B. Ojopi, Sílvia Regina Rogatto, Jos� Roberto F�garo Caldeira, Jose Barbi�ri-Neto, Jeremy A. Squire,
Tópico(s)Genomic variations and chromosomal abnormalities
ResumoGenes, Chromosomes and CancerVolume 30, Issue 1 p. 25-31 Research Article Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast Elida Paula Benquique Ojopi, Elida Paula Benquique Ojopi Department of Genetics, IB-UNESP-Botucatu, São Paulo, BrazilSearch for more papers by this authorSilvia Regina Rogatto, Corresponding Author Silvia Regina Rogatto Department of Genetics, IB-UNESP-Botucatu, São Paulo, BrazilDepartamento de Genetica, IB, UNESP, Botucatu, SP, BrazilSearch for more papers by this authorJosé Roberto Fígaro Caldeira, José Roberto Fígaro Caldeira Amaral Carvalho Hospital, Jaú, São Paulo, BrazilSearch for more papers by this authorJose Barbiéri-Neto, Jose Barbiéri-Neto Department of Pathology, Faculty of Medicine-USP-Ribeirão Preto, São Paulo, BrazilSearch for more papers by this authorJeremy A. Squire, Jeremy A. Squire Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, Ontario Cancer Institute, University of Toronto/Princess Margaret Hospital, Toronto, Ontario, CanadaSearch for more papers by this author Elida Paula Benquique Ojopi, Elida Paula Benquique Ojopi Department of Genetics, IB-UNESP-Botucatu, São Paulo, BrazilSearch for more papers by this authorSilvia Regina Rogatto, Corresponding Author Silvia Regina Rogatto Department of Genetics, IB-UNESP-Botucatu, São Paulo, BrazilDepartamento de Genetica, IB, UNESP, Botucatu, SP, BrazilSearch for more papers by this authorJosé Roberto Fígaro Caldeira, José Roberto Fígaro Caldeira Amaral Carvalho Hospital, Jaú, São Paulo, BrazilSearch for more papers by this authorJose Barbiéri-Neto, Jose Barbiéri-Neto Department of Pathology, Faculty of Medicine-USP-Ribeirão Preto, São Paulo, BrazilSearch for more papers by this authorJeremy A. Squire, Jeremy A. Squire Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, Ontario Cancer Institute, University of Toronto/Princess Margaret Hospital, Toronto, Ontario, CanadaSearch for more papers by this author First published: 25 September 2000 https://doi.org/10.1002/1098-2264(2000)9999:9999 3.0.CO;2-DCitations: 25Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Comparative genomic hybridization analysis was performed for identification of chromosomal imbalances in 23 samples of fibroadenomas of the breast. Chromosomal gains rather than losses were a feature of these lesions. Only two cases with a familial and/or previous history of breast lesions had gain of 1q or 16q as the sole abnormality. The most frequently overrepresented segments were 5p14 (10/23 cases), 5q34–qter (6/23 cases), 13q32–qter (6/23 cases), 10q25–qter (5/23 cases), and 18q22 (4/23 cases). Some of these regions have previously been associated with breast carcinoma, but this study indicates that gain of these regions can also occur in benign breast lesions. Our findings may provide a basis for conducting further investigations to locate and identify genes associated with proliferation that may be involved in the early steps of tumorigenesis of the breast. © 2000 Wiley-Liss, Inc. Citing Literature Volume30, Issue1January 2001Pages 25-31 RelatedInformation
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