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Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

2003; American Association for the Advancement of Science; Volume: 299; Issue: 5603 Linguagem: Inglês

10.1126/science.1078197

1095-9203

Diego J. Walther, Jens‐Uwe Peter, Saleh Bashammakh, Heide Hörtnagl, Mechthild Voits, Heidrun Fink, Michael Bäder,

Tryptophan and brain disorders

The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] is causally involved in multiple central nervous facets of mood control and in regulating sleep, anxiety, alcoholism, drug abuse, food intake, and sexual behavior ([1][1]). In peripheral tissues, 5-HT regulates vascular tone, gut motility,