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Prospective study of exogenous hormone use and breast cancer in seventh-day adventists

1989; Wiley; Volume: 64; Issue: 3 Linguagem: Inglês

10.1002/1097-0142(19890801)64

1097-0142

Paul K. Mills, W. Lawrence Beeson, Roland L. Phillips, Gary E. Fraser,

Estrogen and related hormone effects

CancerVolume 64, Issue 3 p. 591-597 ArticleFree Access Prospective study of exogenous hormone use and breast cancer in seventh-day adventists Paul K. Mills PhD, MPH, Corresponding Author Paul K. Mills PhD, MPH Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CaliforniaDepartment of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350===Search for more papers by this authorW. Lawrence Beeson MSPH, W. Lawrence Beeson MSPH Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CaliforniaSearch for more papers by this authorRoland L. Phillips MD, DrPH, Roland L. Phillips MD, DrPH Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, California Deceased.Search for more papers by this authorGary E. Fraser MD, PhD, Gary E. Fraser MD, PhD Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CaliforniaSearch for more papers by this author Paul K. Mills PhD, MPH, Corresponding Author Paul K. Mills PhD, MPH Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CaliforniaDepartment of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350===Search for more papers by this authorW. Lawrence Beeson MSPH, W. Lawrence Beeson MSPH Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CaliforniaSearch for more papers by this authorRoland L. Phillips MD, DrPH, Roland L. Phillips MD, DrPH Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, California Deceased.Search for more papers by this authorGary E. Fraser MD, PhD, Gary E. Fraser MD, PhD Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CaliforniaSearch for more papers by this author First published: 1 August 1989 https://doi.org/10.1002/1097-0142(19890801)64:3 3.0.CO;2-UCitations: 88 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Exogenous hormone use as either oral contraceptives (OC) or hormone replacement therapy (HRT) was evaluated in reference to subsequent breast cancer risk in a cohort study of 20,341 Seventh-day Adventist women, residing in California, who completed a detailed lifestyle questionnaire in 1976 and who were followed for 6 years. During the follow-up period, 215 histologically confirmed primary breast cancers were detected in the cohort. The mean age at diagnosis was 66 years, indicating a primarily postmenopausal case series. In this cohort, after taking into account potentially confounding variables, current use of HRT (in 1976) was associated with a 69% increase in breast cancer risk, which was statistically significant (RR = 1.69; CI = 1.12–2.55). However, there was no strong increase in risk with increasing duration of use of HRT. Subgroups of women who did experience HRT associated increases in breast cancer risk included those women who had ever used HRT (RR = 1.39; CI = 1.00–1.94) and those with no history of maternal breast cancer (RR = 1.45), those women with prior benign breast disease (RR = 2.80), and those women who experienced menopause at 44 years of age or later (RR = 1.56). There was no substantial increase in breast cancer risk associated with use of OC in this population, although among women with exposure to both OC and HRT there was a suggested increase in risk (RR = 1.42; CI = 0.71–2.85). References 1. Thomas DB, Steroid hormones and medications that alter cancer risks. Cancer 1988; 62: 1755–1767. 10.1002/1097-0142(19881015)62:1+ 3.0.CO;2-5 CASPubMedWeb of Science®Google Scholar 2. Kelsey JL, A review of the epidemiology of human breast cancer. Epidemiol Rev 1979; 1: 74–109. 10.1093/oxfordjournals.epirev.a036215 CASPubMedGoogle Scholar 3. 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