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The Effect of Chlorophenoxyisobutyric Acid and Ethinyl Estradiol on Cholesterol Turnover*

1965; American Society for Clinical Investigation; Volume: 44; Issue: 6 Linguagem: Inglês

10.1172/jci105205

1558-8238

Paul J. Nestel, Eugene Z. Hirsch, Elizabeth A. Couzens,

Cholesterol and Lipid Metabolism

Measurements of cholesterol turnover in man have been reported previously (1-3), but a rela- tionship between turnover and cholesterol concen- tration has not been demonstrated (3).This may be due, in part, to the complex distribution of cholesterol in the body that renders the interpre- tation of isotopic data difficult.Cholesterol exists in the body in a number of separate pools that appear to turn over at differ- ing rates (4).However, Chobanian and Hol- lander (5) and Avigan, Steinberg, and Berman (6) have shown that when labeled cholesterol is injected into man or into the rat, equilibration of the total exchangeable cholesterol in the body is eventually achieved and that the subsequent re- moval of labeled cholesterol from the body repre- sents the turnover of the slowly miscible pool of cholesterol.Since it seemed probable that cholesterol lower- ing drugs would affect the rate at which choles- terol is synthesized or excreted, we have made measurements of cholesterol turnover before and after treatment with cholesterol lowering drugs.We have studied the effects of chlorophenoxyisobutyric acid and ethinyl estradiol and have demon- strated that such studies may provide an indi- cation of the mechanism of action of such drugs. MethodsTen subjects with coronary heart disease, aged 37 to 62, were studied.Eight had had a myocardial infarc- tion approximately 1 year previously, and two suffered from angina pectoris.Three patients were being treated with anticoagulants.The dietary intake was not re- *