Treatment of Advanced Cutaneous Squamous Cell Carcinomas with Epidermal Growth Factor Receptor Inhibitors
2013; Karger Publishers; Volume: 227; Issue: 4 Linguagem: Inglês
10.1159/000355181
ISSN1421-9832
AutoresMareike Alter, Imke Satzger, A. Mattern, Alexander Kapp, Ralf Gutzmer,
Tópico(s)Infectious Diseases and Mycology
ResumoIn advanced cutaneous squamous cell carcinoma (cSCC), efficient medical treatment options are limited in case surgery and radiotherapy failed, particularly since most patients are of higher age and suffer from comorbidities. In many tumor entities, the epidermal growth factor receptor (EGFR) has been established as an important therapeutic target, and blockade of EGFR signaling by monoclonal antibodies or small molecules achieves a therapeutic benefit. EGFR expression is also often dysregulated in cSCC. We report here two patients with advanced cSCC treated with the EGFR inhibitor cetuximab and summarize the current published experience with the use of EGFR inhibitors in cSCC.
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