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Estrogen and/or Progesterone Administered Systemically or to the Amygdala Can Have Anxiety-, Fear-, and Pain-Reducing Effects in Ovariectomized Rats.

2004; American Psychological Association; Volume: 118; Issue: 2 Linguagem: Inglês

10.1037/0735-7044.118.2.306

1939-0084

Cheryl A. Frye, Alicia A. Walf,

Menopause: Health Impacts and Treatments

Estrogen (E2) and/or progesterone (P) in the amygdala may influence anxiety, fear, and pain behaviors. Ovariectomized rats were administered subcutaneous or intra-amygdala vehicle, E2, P, or E2 + P: Effects on open field, elevated plus-maze, defensive freezing, and hot-plate task performance were observed. Subcutaneous E2 + P or intra-amygdala E2, P, or E2 + P increased open field central entries and open arm time in the plus-maze compared with vehicle. Subcutaneous or intra-amygdala E2, P, or E2 + P decreased time spent freezing postshock compared with vehicle. Subcutaneous or intra-amygdala E2 + P increased latencies to lick paws compared with vehicle. Thus, E2 and P may have effects in the amygdala to decrease anxiety, fear, and/or pain responses.