Synthesis and cytotoxicity of enantiomeric pairs of duocarmycin a and its 2-epimer
1992; Elsevier BV; Volume: 2; Issue: 7 Linguagem: Inglês
10.1016/s0960-894x(00)80406-0
ISSN1464-3405
AutoresYasumichi Fukuda, Kazuhiko Nakatani, Shiro Terashima,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoThe synthesis of the four possible diastereomers of duocarmycin A was achieved through optical resolution of a tricyclic synthetic intermidiate. The stereochemical configuration of the cyclopropane ring was found to be closely related with their cytotoxicity against P388 murine leukemia.
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