Artigo Revisado por pares

Synthesis and cytotoxicity of enantiomeric pairs of duocarmycin a and its 2-epimer

1992; Elsevier BV; Volume: 2; Issue: 7 Linguagem: Inglês

10.1016/s0960-894x(00)80406-0

ISSN

1464-3405

Autores

Yasumichi Fukuda, Kazuhiko Nakatani, Shiro Terashima,

Tópico(s)

Bioactive Compounds and Antitumor Agents

Resumo

The synthesis of the four possible diastereomers of duocarmycin A was achieved through optical resolution of a tricyclic synthetic intermidiate. The stereochemical configuration of the cyclopropane ring was found to be closely related with their cytotoxicity against P388 murine leukemia.

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