The carcinogenic effect of aromatic amines: An epidemiological study on the role of o-toluidine and 4,4′-methylene bis (2-methylaniline) in inducing bladder cancer in man
1982; Elsevier BV; Volume: 27; Issue: 2 Linguagem: Inglês
10.1016/0013-9351(82)90079-2
ISSN1096-0953
AutoresGiovanni Rubino, G Scansetti, G Piolatto, Enrico Pira,
Tópico(s)Carcinogens and Genotoxicity Assessment
ResumoCause-specific mortality of 906 workers first employed 1922–1970 in a dyestuff factory in Northern Italy was compared to national figures: a marked excess of bladder cancer was observed (36 observed vs 1.23 expected deaths). The mean latent period was 25 years. The excess was higher among those with longer duration of exposure. Some excess of mortality from lung cancer, laryngeal cancer, and esophageal cancer was also found, but a clear explanation could not be provided regarding the causal role of aromatic amines. Mortality from bladder cancer was very much higher among those exposed in benzidine and naphthylamines manufacture as compared to those only exposed in use or intermittent contact. Excess bladder cancer was also very high among workers in fuchsin manufacture. There is evidence that o-toluidine and 4,4′-methylene bis(2-methylaniline) should be implicated in such excess mortality. Caution in handling these compounds is therefore suggested and the need for further studies to confirm such findings is stressed.
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