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Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age

2004; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês

10.1016/j.vaccine.2004.07.017

1873-2518

Joan Puig‐Barberà, Javier Díez‐Domingo, Santiago Pérez‐Hoyos, Ángel Belenguer‐Varea, David González Vidal,

Respiratory viral infections research

Case–control study designed to determine the effectiveness of an MF59-adjuvanted influenza vaccine in the population aged 65 years and older living in the community. Detailed health histories were obtained on both cases and controls that included a functional measure of co-morbidity (Barthel Index). Subjects were all eligible persons admitted to various hospitals with a diagnosis of pneumonia during the winter months and were matched by sex, hospital and admission week to controls admitted for non-medical reasons. The influenza vaccination programme using the MF59-adjuvanted influenza vaccine significantly reduced the probability of being hospitalised for pneumonia in the elderly over 64 years of age, even in a season with a low influenza activity, during which the predominant circulating strains were types B and A (H1N1).