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Anticancer and antithrombin activity of Russian plants

2002; Elsevier BV; Volume: 81; Issue: 3 Linguagem: Inglês

10.1016/s0378-8741(02)00116-2

1872-7573

Elena A. Goun, В. М. Петриченко, S.U Solodnikov, T.V Suhinina, Martin Kline, Glenn N. Cunningham, Chi L. Nguyen, H. Miles,

Plant biochemistry and biosynthesis

A chromogenic bioassay was utilized to determine the antithrombin activity of the methylene chloride and methanol extracts prepared from forty-five plants of Russia. Mouse leukemia cells (L1210) were utilized to screen these extracts for activity against cancer. The results indicated that eight plant extracts demonstrated 90% or higher activity in the inhibition of thrombin. Also, nine methanol extracts demonstrated activity of 90% or higher in the inhibition of mouse leukemia L1210 cells. The methanol extracts of Quercus robur and Sanguisorba officinalis demonstrated high activity against both thrombin and cancer.