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Absence of effects of prostaglandins E1 and E2 on ganglionic transmission

1968; Elsevier BV; Volume: 4; Issue: 3 Linguagem: Inglês

10.1016/0014-2999(68)90095-2

1879-0712

S.O. Kayaalp, Robert J. McIsaac,

Ion channel regulation and function

The effects of prostaglandins E1 and E2 on ganglionic transmission were assessed using postganglionic action potentials elicited by preganglionic repetitive stimulation of the cervical sympathetic trunk in the cat. Prostaglandin E1 (10–100 μg) given intravenously or intra-arterially did not affect the ganglionic transmission to any detectable extent. Prostaglandin E2 (50–100 μg) was also found to have no effect on the ganglionic transmission. A transient facilitation of transmission by these drugs injected during sith higher frequency was actually a non-specific action due to the vehicle, a weak alcoholic solution. Although a physiological role, possibly a modulatory action, of prostaglandins in the central synapses has been postulated by other investigators on the basis of pertinent experimental evidence, the results obtained in the present work do not support any similar physiological role of these naturally occuring substances in the sympathetic ganglion.