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Astatine-211: Its possible applications in cancer therapy

1986; Pergamon Press; Volume: 37; Issue: 8 Linguagem: Inglês

10.1016/0883-2889(86)90273-x

1878-1128

I. Brown,

Lung Cancer Treatments and Mutations

The cyclotron-produced radiohalogen, 211At, is eminently suitable as a possible therapeutic radionuclide. It decays by the emission of 6.8 MeV mean energy α-particles, which from a radiobiological viewpoint are of near optimal therapeutic LET. This paper reviews developments in the possible application of [211At]astato-labelled molecules as potential anti-tumour agents. Additionally, radio-dosimetric evidence is presented, and its implications for human cancer therapy are discussed.