Portal de Periódicos da CAPES

Aromatic n.c.a. labelling with 18F- by modified Balz-Schiemann-decomposition

1991; Pergamon Press; Volume: 42; Issue: 11 Linguagem: Inglês

10.1016/0883-2889(91)90014-r

1878-1128

Andrei Gavryushin Contributor Paul Knochel, O. Zwernemann,

Fluorine in Organic Chemistry

A modification of the Balz-Schiemann-decomposition has been developed, allowing radiofluorination on n.c.a. level by using the BCl4- instead of the BF4- anion. Using p-toluidyldiazoniumtetrachloroborate as model compound the influence of solvent, anion activation agent and decomposition temperature were studied. Under optimized conditions yields up to 19% of n.c.a. p-fluorotoluene were obtained. This reaction may be a potential tool for obtaining n.c.a. 18F- radiolabelled aromatic compounds, that are not available by direct nucleophilic substitution.