Produção Nacional
Revisado por pares
Antioxidant and orofacial anti-nociceptive activities of the stem bark aqueous extract of Anadenanthera colubrina (Velloso) Brenan (Fabaceae)
2014; Taylor & Francis; Volume: 28; Issue: 10 Linguagem: Inglês
10.1080/14786419.2013.877902
ISSN1478-6427
AutoresNicole Prata Damascena, Marilia T.S. Souza, Amanda Furtado de Almeida, Rafael Soares da Cunha, Nicole Prata Damascena, R.L. Curvello, Amanda C.B. de Lima, Elis Cristiane Valença de Almeida, Clisiane Carla de Souza Santos, Antônio Santos Dias, Mônica Silveira Paixão, Liane Maciel Almeida Souza, Lucindo José Quintans‐Júnior, Charles dos Santos Estevam, Brancilene Santos de Araújo,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoThe anti-nociceptive and antioxidant activities of the Anadenantheracolubrina stem bark aqueous extract (AEAC) were investigated. AEAC (30 μg/mL) reduced 94.8% of 2,2-diphenyl-1-picrylhydrazyl radical and prevented 64% (200 μg/mL) of lipid peroxidation caused by 2,2'-azobis(2-methylpropionamidine) dihydrochloride-induced peroxyl radicals. AEAC treatment (200 and 400 mg/kg) significantly (p < 0.001) reduced mice orofacial nociception in the first (61.4% and 62.6%, respectively) and second (48.9% and 61.9%, respectively) phases of the formalin test. Nociception caused by glutamate was significantly (p < 0.001) reduced by up to 79% at 400 mg/kg, while 56-60% of the nociceptive behaviour induced by capsaicin was significantly inhibited by AEAC (100-400 mg/kg). Mice treated with AEAC did not show changes in motor performance in the Rota-rod apparatus. It appears that AEAC is of pharmacological importance in treating pain due to its anti-nociceptive effects, which were shown to be mediated by central and peripheral mechanisms.
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