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Creating a Reactive Enediyne by Using Visible Light: Photocontrol of the Bergman Cyclization

2007; Wiley; Volume: 46; Issue: 42 Linguagem: Inglês

10.1002/anie.200703034

1521-3773

David Sud, Tony J. Wigglesworth, Neil R. Branda,

Chemical synthesis and alkaloids

Visible changes: Visible light is used to create an active enediyne for Bergman cyclization by taking advantage of a well-known molecular photoswitch. Only isomer 2 has the enediyne structure required to produce a diradical that can be trapped as compound 3. Isomer 2 is formed from the thermally stable isomer 1 by stimulating the ring-opening reaction with visible light.