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Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial

2007; Oxford University Press; Volume: 93; Issue: 2 Linguagem: Inglês

10.1210/jc.2007-1134

1945-7197

Eleanor Gurnell, Penelope J. Hunt, Suzanne Curran, Catherine L. Conway, Eleanor Pullenayegum, Felicia A. Huppert, Juliet Compston, Joseph Herbert, Krishna Chatterjee,

Sexual Differentiation and Disorders

Context: Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are the major circulating adrenal steroids and substrates for peripheral sex hormone biosynthesis. In Addison's disease, glucocorticoid and mineralocorticoid deficiencies require lifelong replacement, but the associated near-total failure of DHEA synthesis is not typically corrected.