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The importance of G-protein βλ subunits

1993; Elsevier BV; Volume: 3; Issue: 7 Linguagem: Inglês

10.1016/0962-8924(93)90122-h

1879-3088

Jorge A. Iñiguez-Lluhı́, Christiane Kleuss, Alfred G. Gilman,

Ion channel regulation and function

As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.