βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
2002; American Association for the Advancement of Science; Volume: 297; Issue: 5582 Linguagem: Inglês
10.1126/science.1073160
ISSN1095-9203
AutoresEric Bachman, Harveen Dhillon, Chen-Yu Zhang, Saverio Cinti, Antônio C. Bianco, Brian K. Kobilka, Bradford B. Lowell,
Tópico(s)Stress Responses and Cortisol
ResumoExcessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through β-adrenergic receptor (βAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism. To test this hypothesis, we created mice that lack the three known βARs (β-less mice). β-less mice on a Chow diet had a reduced metabolic rate and were slightly obese. On a high-fat diet, β-less mice, in contrast to wild-type mice, developed massive obesity that was due entirely to a failure of diet-induced thermogenesis. These findings establish that βARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity.
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