SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold
2002; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês
10.1016/s0959-440x(02)00391-3
ISSN1879-033X
Autores Tópico(s)Epigenetics and DNA Methylation
ResumoThe S-adenosylmethionine-dependent methyltransferase enzymes share little sequence identity, but incorporate a highly conserved structural fold. Surprisingly, residues that bind the common cofactor are poorly conserved, although the binding site is localised to the same region of the fold. The substrate-binding region of the fold varies enormously. Over the past two years, there has been a significant increase in the number of structures that are known to incorporate this fold, including several uncharacterised proteins and two proteins that lack methyltransferase activity.
Referência(s)