Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
2012; Elsevier BV; Volume: 325; Issue: 1 Linguagem: Inglês
10.1016/j.canlet.2012.05.024
ISSN1872-7980
AutoresUlf D. Kahlert, Donata Maciaczyk, Soroush Doostkam, Brent A. Orr, Brian W. Simons, Tomasz Bogiel, Thomas Reithmeier, Marco Prinz, Jörg Schubert, Gabriele Niedermann, Thomas Brabletz, Charles G. Eberhart, Guido Nikkhah, Jarek Maciaczyk,
Tópico(s)Cancer-related gene regulation
ResumoHere we show that activation of the canonical WNT/β-catenin pathway increases the expression of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. Modulation of WNT signaling alters the expression of epithelial-to-mesenchymal transition activators, suggesting a role of this process in the regulation of glioma motility. Using immunohistochemistry in patient-derived glioblastoma samples we showed higher numbers of cells with intranuclear signal for β-catenin in the infiltrating edge of tumor compared to central tumor parenchyma. These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target.
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