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A Poly(oxyethylene)-Supported Cys–Pro–Leu–Cys/Fe(II) Complex as a Rubredoxin Model: Protection of the Fe–Cys Coordination from Hydrolysis in Aqueous Solution

1985; Springer Nature; Volume: 17; Issue: 5 Linguagem: Inglês

10.1295/polymj.17.721

1349-0540

Norikazu Ueyama, Michio Nakata, Akira Nakamura,

Magnetism in coordination complexes

Hg(II) and Fe(II) complexes of PEG–CO–Cys–Pro–Leu–Cys–OMe (PEG = poly(oxyethylene)) each having an invariant sequence of rubredoxin were synthesized. The complexes were characterized by 13C NMR and CD spectral methods. In aqueous solution, the Fe(II) complex is considerably resistant to hydrolysis compared to the Fe(II) complex of PEG–CO–Cys–OMe because of protection of the Fe(II) core by hydrophobic side chains of Pro and Leu residues.