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Der Einfluss anhaltender hoher O 2 ‐Konzentration der Einatmungsluft (30–100%) auf die Erythropoiese der Ratte

1963; Wiley; Volume: 57; Issue: 4 Linguagem: Inglês

10.1111/j.1748-1716.1963.tb02603.x

1365-201X

Bernhard Tribukait,

Erythropoietin and Anemia Treatment

Abstract Rats were subjected to oxygen concentrations of 30—100% for 8—10 weeks. Total hemoglobin, blood volume and relative blood values were determined. The lungs were unaffected by oxygen concentrations up to 80%. The total hemoglobin and the blood values remained essentially normal although the reticulocytes occasionally decreased appreciably. Acute and chronic lung lesions developed in rats subjected to 100% oxygen concentration. If they survived the initial lesions they were left in the 100% oxygen concentration for 10 weeks and were then placed in an environment of room air for 6 weeks. Upon return to 100% oxygen concentration no further acute lesions of the lungs occurred. The erythropoiesis was markedly influenced by the lung damage.