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One-pot synthesis of 1,2,3-triazoles from boronic acids in water using Cu(ii)–β-cyclodextrin complex as a nanocatalyst

2012; Royal Society of Chemistry; Volume: 10; Issue: 23 Linguagem: Inglês

10.1039/c2ob25061f

1477-0539

Babak Kaboudin, Yaghoub Abedi, Tsutomu Yokomatsu,

HIV/AIDS drug development and treatment

We report here the one-pot synthesis of 1,2,3-triazoles of arylboronic acids in water. An efficient method has been developed for the synthesis of 1,2,3-triazoles via a one-pot reaction of an arylboronic acid with sodium azide in the presence of Cu2–β-CD (CD = Cyclodextrin) as a nanocatalyst in water followed by a click cyclization reaction with an alkyne at room temperature in air without any additives. This method is simple, rapid, and high yielding.