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Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome

1998; Elsevier BV; Volume: 160; Issue: 1 Linguagem: Inglês

10.1016/s0022-510x(98)00238-x

1878-5883

Chiaki Kawanishi, Yoshikazu Shimoda, Jun Fujimaki, Hideki Onishi, Kyoko Suzuki, Tokiji Hanihara, Naoya Sugiyama, Kenji Kosaka,

Hormonal Regulation and Hypertension

Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.