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Plasmon-Based Nanolenses Assembled on a Well-Defined DNA Template

2008; American Chemical Society; Volume: 130; Issue: 9 Linguagem: Inglês

10.1021/ja711074n

1943-2984

Sébastien Bidault, F. Javier Garcı́a de Abajo, Albert Polman,

RNA Interference and Gene Delivery

The controlled and reproducible synthesis of closely spaced noble metal nanoparticle groupings is an essential step toward the rational design of nanostructures for surface enhanced Raman scattering with single-molecule sensitivity. In this communication, we demonstrate the facile synthesis of 5, 8, and 18 nm gold particle groupings on a well-defined DNA template by hybridizing monoconjugated gold−DNA building blocks. The obtained nanometer interparticle gaps should yield local intensity enhancements up to 4 orders of magnitude as estimated by Generalized Mie Theory. By tuning the particle size and relative curvatures, we calculate that the maximum enhancement can be optimized and localized on a specific part of the nanostructure. These groupings act as plasmon-based nanolenses assembled on a biomolecular backbone that can be functionalized in proximity to the region of highest field.